Why Do Healthy Parents Have Babies with Genetic Abnormalities?

 Insights from Dr. Deep Malu – The Best Fertility Doctor in Nizamabad | Nova Life Hospital



The birth of a child is one of life’s greatest joys. But sometimes, even when both parents are healthy and have no known medical issues, their baby may be born with a genetic abnormality. This can be emotionally challenging and confusing for families who wonder — “Why did this happen to us?” or “Will it happen again in future pregnancies?”

In this article, Dr. Deep Malu, one of the best fertility doctor in Nizamabad at Nova Life Hospital, explains why genetic abnormalities can occur even when parents appear normal and how advanced medical screening and fertility treatments can help reduce such risks.

Understanding Genetic Abnormalities

Genetic abnormalities refer to changes or mutations in a baby’s genes or chromosomes. These can affect physical appearance, organ function, or cause developmental disorders. Despite significant advances in medical science and prenatal genetic screening, some genetic abnormalities still occur due to random biological processes.

At Nova Life Hospital, Nizamabad, our expert team led by Dr. Deep Malu provides advanced fertility treatments and genetic counseling to help couples understand and manage these risks effectively.

1. Chromosomal Number Deviations

Each human cell normally contains 46 chromosomes, arranged in 23 pairs — half from the mother’s egg and half from the father’s sperm. These chromosomes carry all the genetic information that determines a person’s traits and health.

However, if the number of chromosomes deviates from normal — either extra or missing — it can result in chromosomal disorders.

Some common examples include:

  • Down Syndrome (Trisomy 21)

  • Edwards Syndrome (Trisomy 18)

  • Patau Syndrome (Trisomy 13)

Such abnormalities occur when an egg or sperm cell contains an incorrect number of chromosomes due to errors during cell division. This is known as nondisjunction — and it can happen randomly in anyone, even healthy parents.

The risk increases with maternal age, especially in women above 35 years.

During fertility treatments like IVF, Dr. Deep Malu recommends Preimplantation Genetic Testing (PGT-A, PGT-M, or PGT-SR) to detect chromosomal abnormalities in embryos before implantation. This ensures that only healthy embryos are transferred, significantly reducing the risk of genetic diseases.

2. Structural Changes in Chromosomes

Sometimes, even when the chromosome count is normal, their structure may change. Segments of chromosomes may break off, duplicate, or attach incorrectly to another chromosome.

While a parent with such a structural rearrangement may be perfectly healthy, they can unknowingly pass on an unbalanced chromosome to their child, causing a genetic disorder.

Some examples of disorders caused by structural abnormalities include:

  • Cri-du-chat Syndrome (deletion on chromosome 5)

  • DiGeorge Syndrome (deletion on chromosome 22)

These changes usually occur randomly during the formation of eggs or sperm and are not inherited from the parent’s previous generations.

At Nova Life Hospital, fertility specialists perform advanced genetic evaluations for couples with a family history of genetic issues or previous pregnancy losses to identify such risks early.

3. Single Gene Mutations

Apart from chromosomal abnormalities, certain conditions are caused by mutations in a single gene. Every gene exists in pairs and may have different forms, known as alleles. Some alleles are dominant (always expressed), while others are recessive (only expressed if both copies are defective).

When both parents carry one defective recessive gene (without showing any symptoms themselves), their child has a 25% chance of inheriting both defective copies — resulting in the disease.

Common single-gene disorders include:

  • Thalassemia

  • Haemophilia

  • Spinal Muscular Atrophy (SMA)

This is another reason why normal parents can have a baby with a genetic abnormality.

To minimize such risks, Dr. Deep Malu, the best fertility doctor in Nizamabad, recommends genetic carrier screening before conception or during IVF planning. Identifying carrier status early allows couples to make informed decisions and explore preventive options such as PGT-M testing.

How Modern Fertility Care Helps

At Nova Life Hospital, our fertility specialists combine advanced genetic testing, IVF technology, and personalized counseling to support couples through every stage of their fertility journey.

Services include:

  • Preconception genetic counseling for couples with a family history of genetic disorders.

  • Preimplantation Genetic Testing (PGT) for embryos during IVF.

  • Prenatal screening and diagnostic scans during pregnancy.

  • High-risk pregnancy management under experienced gynecologists and fertility doctors.

With the latest reproductive technologies and compassionate care, Dr. Deep Malu ensures that couples have the best chance of achieving a healthy pregnancy and baby.

When to Consult a Fertility Specialist

You should consider consulting a fertility doctor in Nizamabad if:

  • You or your partner have a family history of genetic diseases.

  • You have experienced multiple miscarriages or failed pregnancies.

  • You are planning pregnancy after the age of 35.

  • You are considering IVF or ICSI treatment and want to ensure genetic normality in your baby.

Early consultation with Dr. Deep Malu at Nova Life Hospital helps you identify potential genetic risks and plan a safer pregnancy.

Final Thoughts

Genetic abnormalities can occur even when both parents are healthy. These changes are often random and beyond one’s control. However, with modern fertility treatments, genetic testing, and expert guidance, couples can significantly reduce the risk of having a child with a genetic disorder.

At Nova Life Hospital, Nizamabad, under the expert care of Dr. Deep Malu, couples receive advanced reproductive care, thorough screening, and personalized counseling to ensure a healthy start to parenthood.

📍 Visit: Nova Life Hospital, Saraswati Nagar, Nizamabad
 📞 Call: 9392552845
 🌐 Website: www.novalifehospitals.com

Dr. Deep Malu – The Best IVF & Fertility Doctor in Nizamabad
 Your trusted partner in fertility, genetics, and safe pregnancy care.

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